Ovarian Cancer Latest Research and Early Detection

2022-23 Grantees

DIPANJAN CHOWDHURY, PhD & KEVIN ELIAS, MD

Project Title: “Circulating microRNA signatures among BRCA1/2 mutation carriers”

Dr. Chowdhury is a Professor of Medicine at Harvard Medical School and Chief of the Division of Radiation and Genome Stability in the Department of Radiation Oncology at the Dana-Farber Cancer Institute. Dr. Elias is an Assistant Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School and a Gynecologic Oncologist and Director of the Gynecologic Oncology Laboratory at Brigham And Women's Hospital.

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Ie-Ming Shih, MD, PhD, Thomas R. Pisanic II, PhD & Tza-Huei “Jeff” Wang, PhD

Project Title: “PapDREAMS - a combined genetic and epigenetic multi-analyte assay for early detection of ovarian cancer in tissue proximal fluids”

Dr. Shih is a Richard W. TeLinde Distinguished Professor in the Department of Gynecology and Obstetrics at the Johns Hopkins University School of Medicine and a board-certified attending pathologist in the Division of Gynecologic Pathology at the Johns Hopkins Hospital. Dr. Pisanic is a Senior Research Scientist at The Johns Hopkins Institute for NanoBioTechnology. Dr. Wang is a professor in the Departments of Mechanical Engineering and Biomedical Engineering at the Johns Hopkins University and a Core Researcher at the Johns Hopkins Institute for NanoBioTechnology.

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Lan Coffman, MD, PhD & Thomas R. Pisanic II, PhD

Project Title: “Stromal biomarkers for enhanced detection of early-stage ovarian cancer”

Dr. Coffman is an Assistant Professor of hematology/oncology in the division of gynecologic oncology at the University of Pittsburgh and a physician scientist at Magee-Women's Research Institute & Foundation. Dr. Pisanic is a Senior Research Scientist at the Johns Hopkins Institute for NanoBioTechnology.

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Daniel A. Heller, PhD & Kara Long Roche, MD

Project Title: “Monitoring Intrauterine Biomarkers to Detect Pre-Invasive Disease”

Dr. Heller is head of the Cancer Nanomedicine Laboratory at Memorial Sloan Kettering. Dr. Long Roche is a gynecologic oncologist at the Memorial Sloan Kettering Cancer Center. Dr. Long Roche and Dr. Heller are Co-Principal Investigators on this project.

Many thanks to Douglas A. Levine, MD, of NYU Perlmutter Cancer Center, for his contributions as Co-PI during the first phase of this project.

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Ronny Drapkin, MD, PhD & Jarrod Marto, PhD

Project Title: “Bioanalytical platform for identification and validation of ovarian cancer biomarkers in tissues and proximal fluids"

Dr. Drapkin is an Associate Professor of Obstetrics, Gynecology and Pathology at the University of Pennsylvania and the Director of the Ovarian Cancer Research Center at Penn Medicine. Dr. Marto is an Associate Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Director of the Blais Proteomics Center and Principal Investigator for the Department of Cancer Biology at Dana-Farber Cancer Institute. Dr. Drapkin and Dr. Marto are Co-Principal Investigators on this project.

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Gottfried Konecny, MD & Victor Velculescu, MD, PhD

Project Title: “Non-invasive liquid biopsy approach for early detection of ovarian cancer using cell free DNA fragmentation patterns”

Dr. Konecny is a Professor of Oncology and Obstetrics and Gynecology, and the Director of Medical Gynecologic Oncology at UCLA. Dr. Velculescu is Co-Director of Cancer Genetics and Epigenetics, and a Professor of Oncology and Pathology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

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Chuan He, PhD & Ernst Lengyel, MD, PhD

Project Title: “Epigenetic cell-free DNA biomarkers for ovarian cancer detection”

Dr. He is a chemical biologist and the John T. Wilson Distinguished Service Professor at the University of Chicago. Dr. Lengyel is an Arthur L. and Lee G. Herbst Professor of Obstetrics and Gynecology and Chair of the Department of Obstetrics and Gynecology at University of Chicago.

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Andrew K. Godwin, PhD & Steven Soper, PhD

Project Title: “Liquid Biopsy using Tumor Specific Extracellular Vesicles for the Early Detection of Epithelial Ovarian Cancer”

Dr. Godwin is the Chancellors Distinguished Chair in Biomedical Sciences, Endowed Professor, and Director of Molecular Oncology, Pathology and Laboratory Medicine at The University of Kansas Medical Center. In the fall of 2019, Dr. Godwin was named the recipient of the Dolph Simons Award in the Biomedical Sciences. Dr. Soper is a Foundation Distinguished Professor at The University of Kansas and holds joint appointments in the Departments of Chemistry and Mechanical Engineering.

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Rising Star Grant, Kevin Liaw, PhD

Project Title: "Identifying novel cytolytic T lymphocyte epitopes of follicle-stimulating hormone receptor for the design of DNA-launched nanoparticle vaccines against ovarian cancers"

Dr. Kevin Liaw is postdoctoral fellow at the Wistar Institute in the Weiner Lab.

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#1

deadliest gynecologic
cancer

80%

of women are diagnosed
at an advanced stage

27%

of women have a 5-year
survival rate after an
advanced stage diagnosis