Ovarian Cancer Latest Research and Early Detection

Current Research

Simon Gayther, PhD

Project Title: “Identifying molecular targets for prevention of P53 mutant serous tubal intraepithelial carcinomas”

Dr. Gayther is the Barth Family Chair in Cancer Genetics, Director of Molecular Epidemiology, Department of Biomedical Sciences, and Co-Director of the Center for Bioinformatics and Functional Genomics at Cedars-Sinai Medical Center, Los Angeles.

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DIPANJAN CHOWDHURY, PhD

Project Title: “Monitoring and detection of ovarian cancer using serum microRNA signatures in high-risk families”

Dr. Chowdhury is an Associate Professor of Medicine at Harvard Medical School and an Associate Professor of Radiation Oncology at the Dana-Farber Cancer Institute.

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Ie-Ming Shih, MD, PhD

Project Title: “PapDREAMing for the detection of premalignant ovarian cancer”

Dr. Shih is the Richard W. TeLinde Distinguished Professor in the Department of Gynecology and Obstetrics at the Johns Hopkins University School of Medicine and a board-certified attending pathologist in the Division of Gynecologic Pathology at the Johns Hopkins Hospital.

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Andrew K. Godwin, PhD, Steven Soper, PhD, & Claudio Soto, PhD

Project Title: “Developing a misfolded p53 aggregation assay to interrogate disease-specific exosomes captured using a microfluidic device for the early detection of epithelial ovarian cancer”

Dr. Godwin is the Chancellors Distinguished Chair in Biomedical Sciences endowed Professor and the Director of Molecular Oncology at The University of Kansas Medical Center. Dr. Godwin was the 2019 recipient of the Dolph Simons Award in the Biomedical Sciences. Dr. Soper is a Foundation Distinguished Professor at The University of Kansas and holds joint appointments in the Departments of Chemistry and Mechanical Engineering. Dr. Soto is the Huffington’s Distinguished University Chair, Professor of Neurology and Director of George and Cynthia Mitchell Center for Alzheimer’s Disease and Related Brain Disorders at The University of Texas Medical School in Houston.

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Daniel A. Heller, PhD & Douglas A. Levine, MD

Project Title: “Clinical Development of an Implantable Nanosensor for Early-Stage Ovarian Cancer Detection”

Dr. Heller is head of the Cancer Nanomedicine Laboratory at Memorial Sloan Kettering. Dr. Levine is the Director of Gynecologic Oncology, Head of the Gynecology Research Laboratory and a Professor at NYU Langone Perlmutter Cancer Center. Dr. Levine is also Chair of the Tina’s Wish Scientific Advisory Board. Dr. Levine and Dr. Heller are Co-Principal Investigators on this project.

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Samuel C. Mok, PhD

Project Title: “Identification of ovarian cancer biomarkers in women at high risk of developing ovarian cancer using emerging EFIRM Liquid Biopsy (eLB) technology”

Dr. Mok holds the Stephanie C. Stelter Professorship in the Department of Gynecologic Oncology & Reproductive Medicine at The University of Texas MD Anderson Cancer Center.

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Ronny Drapkin, MD, PhD & Jarrod Marto, PhD

Project Title: “Biomarker Discovery and Validation in Tissue Proximal Fluids”

Dr. Drapkin is an Associate Professor of Obstetrics, Gynecology and Pathology at the University of Pennsylvania and the Director of the Ovarian Cancer Research Center at Penn Medicine. Dr. Marto is an Associate Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Director of the Blais Proteomics Center and Principal Investigator for the Department of Cancer Biology at Dana-Farber Cancer Institute. Dr. Drapkin and Dr. Marto are Co-Principal Investigators on this project.

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Abhijit Patel, MD, PhD & Alessandro Santin, MD

Project Title: “Integrated Analysis of Proteomic and Genomic Signatures in Blood for Early Detection of Ovarian Cancer”

Dr. Patel is an Assistant Professor of Therapeutic Radiology at Yale Cancer Center. Dr. Santin is a Professor of Obstetrics, Gynecology, and Reproductive Sciences at Yale Cancer Center. Dr. Patel and Dr. Santin are Co-Principal Investigators on this project.

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Rising Star Grant, Kevin Elias, MD

Project Title: “A murine model for early ovarian cancer detection using circulating microRNA”

Dr. Elias is a physician-scientist in Gynecologic Oncology with appointments at Brigham and Women’s Hospital, the Dana-Farber Cancer Institute, and Harvard Medical School.

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Rising Star Grant, Maria Sol Recouvreux , PhD

Project Title: “The Role of Ciliated Cells in Preventing Fallopian Tube Cancer Initiation”

Dr. Recouvreux is a postdoctoral fellow in the Women’s Cancer Program at Cedars-Sinai Medical Center.

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Rising Star Grant, Sarah Hill, MD, PhD

Project Title: “Deciphering the mechanisms and relevance of replication stress in ovarian cancer precursor cells”

Dr. Hill is a gynecologic pathologist and an independent investigator at Dana-Farber Cancer Institute.

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Rising Star Grant, Lan Gardner Coffman, MD, PhD

Project Title: “Targeting the formation of carcinoma-associated mesenchymal stem cells to prevent the establishment of the ovarian cancer microenvironment”

Dr. Coffman is a clinical lecturer in the division of Hematology/Oncology at the University of Pittsburgh. She is board certified in internal medicine and medical oncology and is pursuing a career as a physician-scientist with a clinical focus on ovarian cancer and research focus on the tumor microenvironment.

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Rising Star Grant, Alexandra R. Harris, PhD

Project Title: “Endocervical microRNA profiling for early detection of ovarian cancer”

Dr. Harris is a postdoctoral research student in the Department of Obstetrics and Gynecology at the University of Virginia

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Consortium Grant, Ronny Drapkin, MD, PhD, Daniel Heller, PhD, Ie-Ming Shih, MD, PhD, Rugang Zhang, PhD

Project Title: “Integration of Advanced Genomic and Bioengineering Approaches for Early Detection and Prevention of Ovarian Cancer”

Tina's Wish is honored to present its second Consortium Grant to this cutting edge team of researchers who will collaborate together for the next three years.

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#1

deadliest gynecologic
cancer

80%

of women are diagnosed
at an advanced stage

27%

of women have a 5-year
survival rate after an
advanced stage diagnosis